Cranial suture morphogenesis

Across TCGA patient cohorts, RNA activity of the Cranial suture morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP9, CNN3, and CTHRC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial suture morphogenesis activity versus FKBP9 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FKBP9 →	+0.495	+0.086	<.001	<.001	3	9
OV	CNN3 →	+0.681	+0.080	<.001	<.001	3	8
OV	CTHRC1 →	+0.990	+0.090	<.001	<.001	3	8
OV	FHL3 →	+0.673	+0.091	<.001	<.001	3	8
OV	FKBP7 →	+0.813	+0.125	<.001	<.001	3	8
OV	FN1 →	+1.154	+0.099	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060363 vs FKBP9 — LSCC

Explore this scatter interactively →