Cranial suture morphogenesis

Across TCGA cell cohorts, RNA activity of the Cranial suture morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA7, LZIC, and NADK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA7 grouped by Cranial suture morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GOLGA7 →	+0.531	+1.269	<.001	.001	3	4
OESOPHAGUS	LZIC →	-0.711	-1.303	.001	.004	3	4
PANCREAS	NADK2 →	-0.931	-0.944	.002	.006	3	4
LUNG_NSCLC_LUAD	MAD2L2 →	-0.920	-0.950	<.001	.001	3	3
LUNG_NSCLC_LUAD	SLC66A1 →	-0.532	-0.760	<.001	<.001	3	3
LUNG_NSCLC_LUAD	USP48 →	-0.542	-0.869	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA7 by Cranial suture morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →