Response to ammonium ion

Across TCGA patient cohorts, RNA activity of the Response to ammonium ion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPS1, TSKU, and PSMA6P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ammonium ion activity versus CPS1 in LUAD (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CPS1 →	+2.369	+0.188	<.001	<.001	3	3
BRCA	TSKU →	-1.057	-0.119	<.001	.007	3	3
BRCA	PSMA6P2 →	+0.392	+0.144	.001	.001	3	3
LUAD	GAB1 →	-0.436	-0.155	.002	.008	3	3
LUAD	TMBIM6 →	+0.227	+0.139	.001	.002	3	3
LUAD	CFL1P1 →	-0.211	-0.199	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060359 vs CPS1 — LUAD

Explore this scatter interactively →