Response to ammonium ion

Across TCGA pan-cancer cohorts, RNA activity of the Response to ammonium ion pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Response to ammonium ion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and CESC, show the opposite pattern, with higher activity associated with better survival.

UCS, KIRP, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	III,IV	0.129	0.459	.004	68	view →
KIRP	OS	Median	III,IV	0.722	0.245	.001	67	view →
CESC	OS	Median	All	0.931	0.819	.002	50	view →
COAD	DFS	Quartile	All	0.795	0.615	.003	39	view →
KIRC	DFS	Quartile	All	0.935	0.812	.002	34	view →
MESO	OS	Median	II,III,IV	0.660	0.465	.011	29	view →
PAAD	DFS	Quartile	All	0.143	0.480	.002	25	view →
OV	OS	Tertile	II,III,IV	0.413	0.318	.015	24	view →
LGG	DFS	Quartile	All	0.775	0.599	<.001	22	view →
THCA	DFS	Tertile	II,III,IV	0.947	0.667	.007	15	view →
UCEC	DFS	Median	All	0.860	0.928	<.001	14	view →
BLCA	OS	Quartile	III,IV	0.560	0.291	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0060359–UCS (DFS)

Open the UCS breakdown →