Response to ammonium ion

Across TCGA cell cohorts, RNA activity of the Response to ammonium ion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN18, TCERG1, and USF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ammonium ion activity versus PTPN18 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTPN18 →	+0.693	+0.280	.002	.001	3	3
BLOOD_Myeloma	TCERG1 →	-0.618	-0.332	.005	.005	3	3
BREAST	USF2 →	+0.837	+0.261	.002	.002	3	2
BREAST	ASS1 →	+2.081	+0.283	<.001	<.001	3	2
BREAST	VPS45 →	+0.825	+0.314	.001	.002	3	2
BREAST	MDC1 →	+0.645	+0.251	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060359 vs PTPN18 — BREAST

Explore this scatter interactively →