Cartilage development involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Cartilage development involved in endochondral bone morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP2, ILK, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cartilage development involved in endochondral bone morphogenesis activity versus EFEMP2 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EFEMP2 →	+0.584	+0.037	<.001	<.001	3	9
BRCA	ILK →	+0.367	+0.038	<.001	<.001	3	9
OV	PRKG1 →	+0.487	+0.051	<.001	<.001	3	9
CCRCC	SVIL →	+0.369	+0.040	<.001	<.001	3	8
OV	SEPTIN11 →	+0.422	+0.070	<.001	<.001	3	8
PDAC	SORBS3 →	+0.276	+0.042	.006	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060351 vs EFEMP2 — BRCA

Explore this scatter interactively →