Cartilage development involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Cartilage development involved in endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFC, SRPX2, and PRKD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cartilage development involved in endochondral bone morphogenesis activity versus VEGFC in OV (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VEGFC →	+0.589	+0.221	.006	.001	3	6
OV	SRPX2 →	+0.964	+0.239	<.001	<.001	3	5
LUAD	PRKD1 →	+0.735	+0.681	.001	.002	3	5
BRCA	C4orf47 →	+0.632	+0.653	.001	<.001	3	5
COAD	SLIT2 →	+0.680	+0.939	.009	<.001	3	4
OV	PTH1R →	+0.724	+0.228	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060351 vs VEGFC — OV

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