Endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Endochondral bone morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21, HSPA12B, and ILK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endochondral bone morphogenesis activity versus DDX21 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX21 →	-0.451	-0.030	.001	<.001	3	10
BRCA	HSPA12B →	+0.503	+0.029	<.001	<.001	3	10
BRCA	ILK →	+0.417	+0.033	<.001	<.001	3	10
PDAC	ISLR →	+0.695	+0.034	<.001	<.001	3	10
GBM	LUM →	+0.821	+0.039	.006	.007	3	10
UCEC	OLFML3 →	+0.808	+0.051	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060350 vs DDX21 — BRCA

Explore this scatter interactively →