Endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSHZ3, COL6A3, and FBN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endochondral bone morphogenesis activity versus TSHZ3 in OV (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TSHZ3 →	+0.603	+0.381	.001	.002	3	7
OV	COL6A3 →	+1.280	+0.476	<.001	<.001	3	7
OV	FBN1 →	+1.691	+0.625	<.001	.001	3	7
OV	CHSY3 →	+0.753	+0.538	.005	.006	3	7
COAD	PXDN →	+0.829	+0.778	.004	.001	3	7
OV	SYDE1 →	+0.531	+0.348	.007	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060350 vs TSHZ3 — OV

Explore this scatter interactively →