Endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERM1, COX6B2, and ERCC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PERM1 grouped by Endochondral bone morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PERM1 →	-0.904	-0.930	<.001	.001	3	5
OESOPHAGUS	COX6B2 →	-2.346	-0.250	.002	.003	3	5
SKIN	ERCC3 →	+0.271	+0.734	.002	<.001	3	4
CNS	ASB9 →	+1.561	+0.926	<.001	.001	3	4
LUNG_NSCLC_LUSC	TRUB1 →	+0.718	+1.593	.004	<.001	3	4
LUNG_NSCLC_LUAD	GDE1 →	+0.682	+0.655	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PERM1 by Endochondral bone morphogenesis activity — STOMACH

Explore this box plot interactively →