Endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP4, RRAGD, and ADCY6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endochondral bone morphogenesis activity versus BMP4 in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BMP4 →	+3.429	+0.113	.002	<.001	3	7
SKIN	RRAGD →	-1.830	-0.117	<.001	<.001	3	7
BONE	ADCY6 →	+0.668	+0.105	.002	<.001	2	8
SOFT_TISSUE	SERTAD3 →	+0.621	+0.094	.005	.004	3	6
SKIN	SLC25A19 →	-0.528	-0.064	.004	.001	3	6
CNS	PDCD2L →	-0.605	-0.090	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060350 vs BMP4 — STOMACH

Explore this scatter interactively →