Endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPP40, CMBL, and ST6GALNAC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endochondral bone morphogenesis activity versus RPP40 in LUNG_NSCLC_LUSC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RPP40 →	-1.353	-1.841	.009	<.001	3	4
LUNG_SCLC	CMBL →	+2.104	+0.971	.002	.004	3	4
LUNG_SCLC	ST6GALNAC2 →	+1.653	+1.290	.002	<.001	3	4
BLOOD_Lymphoma	NSMF →	-0.621	-0.899	.007	.002	3	4
LUNG_NSCLC_LUSC	RHPN2 →	-0.791	-1.841	.007	<.001	3	3
LUNG_NSCLC_LUSC	FBN2 →	+3.234	+1.841	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060350 vs RPP40 — LUNG_NSCLC_LUSC

Explore this scatter interactively →