Heart trabecula formation

Across TCGA patient cohorts, RNA activity of the Heart trabecula formation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, SYNPO2_T755, and COL18A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula formation activity versus SYNPO2 in COAD (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SYNPO2 →	+0.753	+0.030	.002	.002	3	8
GBM	SYNPO2_T755 →	+1.167	+0.082	<.001	<.001	3	8
COAD	COL18A1 →	+0.401	+0.033	.001	<.001	3	8
COAD	KANK2 →	+0.585	+0.038	<.001	<.001	3	8
LUAD	MIOS_S766 →	-0.512	-0.057	<.001	.005	3	8
COAD	LAMC1 →	+0.635	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060347 vs SYNPO2 — COAD

Explore this scatter interactively →