Trabecula formation

Across TCGA patient cohorts, RNA activity of the Trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL14A1, COL15A1, and HSPG2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula formation activity versus COL14A1 in UCS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	COL14A1 →	+2.412	+0.079	<.001	<.001	3	27
DLBC	COL15A1 →	+1.893	+0.034	.001	.001	2	28
TGCT	HSPG2 →	+1.848	+0.074	<.001	<.001	3	26
THYM	CCDC3 →	+1.607	+0.059	<.001	<.001	3	26
TGCT	MSRB3 →	+1.486	+0.073	<.001	<.001	3	25
STAD	ACTA2-AS1 →	+1.194	+0.074	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060343 vs COL14A1 — UCS

Explore this scatter interactively →