Trabecula formation

Across TCGA patient cohorts, RNA activity of the Trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALD1, CALHM5, and FBN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula formation activity versus CALD1 in COAD (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CALD1 →	+0.912	+0.559	.001	<.001	3	9
COAD	CALHM5 →	+0.722	+0.455	<.001	.002	3	8
BRCA	FBN1 →	+0.942	+0.395	.002	.005	3	7
COAD	CAVIN1 →	+0.867	+0.475	.005	.001	2	8
BRCA	COL15A1 →	+0.992	+0.432	<.001	.006	3	7
CCRCC	CYBRD1 →	+0.830	+0.300	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060343 vs CALD1 — COAD

Explore this scatter interactively →