Trabecula formation

Across TCGA cell cohorts, RNA activity of the Trabecula formation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL3, FOXE1, and RBP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYL3 grouped by Trabecula formation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYL3 →	-0.442	-2.182	<.001	<.001	3	5
BLOOD_Myeloma	FOXE1 →	-0.422	-1.360	.004	.004	3	5
KIDNEY	RBP4 →	-0.428	-1.711	.003	.001	3	5
SOFT_TISSUE	WNT10B →	-0.206	-1.304	.002	.001	3	5
BLOOD_Myeloma	MYOZ3 →	-0.232	-2.200	.008	<.001	3	4
LUNG_SCLC	KCTD2 →	-0.284	-1.200	.007	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYL3 by Trabecula formation activity — BLOOD_Myeloma

Explore this box plot interactively →