Trabecula formation

Across TCGA cell cohorts, RNA activity of the Trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELI1, SMTN, and MYG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula formation activity versus PELI1 in URINARY_TRACT (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PELI1 →	-1.266	-2.069	.003	<.001	3	4
SKIN	SMTN →	+1.700	+0.498	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	MYG1 →	+0.686	+2.279	.009	<.001	3	4
SOFT_TISSUE	NCEH1 →	+3.805	+1.863	.009	<.001	2	4
URINARY_TRACT	RABGAP1L →	-1.657	-1.711	.006	<.001	3	3
OVARY	MRPL2 →	+0.707	+2.241	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060343 vs PELI1 — URINARY_TRACT

Explore this scatter interactively →