Regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTROB, PRR15, and SLC9A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTROB grouped by Regulation of type I interferon-mediated signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CNTROB →	-0.732	-0.539	<.001	.002	3	4
BREAST	PRR15 →	+2.305	+0.680	<.001	.002	3	4
LIVER	SLC9A2 →	+1.458	+0.315	<.001	.001	3	4
LARGE_INTESTINE	MAP7 →	+1.392	+0.683	.008	.006	2	5
LARGE_INTESTINE	ADGRF4 →	+1.277	+0.916	.004	<.001	3	4
CNS	CENPE →	-0.853	-0.973	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTROB by Regulation of type I interferon-mediated signaling pathway activity — BREAST

Explore this box plot interactively →