Type II interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Type II interferon-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB6, PPP4C, and TAF8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB6 grouped by Type II interferon-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMB6 →	-0.548	-0.151	.001	.001	2	8
STOMACH	PPP4C →	-0.447	-0.247	.003	.002	3	6
LARGE_INTESTINE	TAF8 →	-0.238	-0.126	<.001	.001	3	6
LUNG_SCLC	UFC1 →	+0.270	+0.191	.005	.001	3	6
STOMACH	ANAPC5 →	+0.376	+0.174	.004	.007	3	5
OVARY	P2RY4 →	+0.200	+0.156	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB6 by Type II interferon-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →