Positive regulation of response to type II interferon

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to type II interferon pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2L6, IRF9, and NMI, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to type II interferon activity versus UBE2L6 in COAD (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2L6 →	+0.584	+0.091	<.001	<.001	3	10
GBM	IRF9 →	+0.420	+0.118	<.001	<.001	3	10
HNSC	NMI →	+0.533	+0.094	<.001	<.001	3	10
LSCC	PSMB6 →	-0.421	-0.090	<.001	<.001	3	10
LSCC	RNF213 →	+0.404	+0.106	<.001	<.001	3	9
HNSC	SAMHD1 →	+0.445	+0.078	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060332 vs UBE2L6 — COAD

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