Positive regulation of response to type II interferon

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREBL2, C12orf65, and BARX2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREBL2 grouped by Positive regulation of response to type II interferon-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CREBL2 →	+1.119	+1.545	.003	.002	3	3
KIDNEY	C12orf65 →	+0.497	+1.475	.002	.004	3	3
KIDNEY	BARX2 →	+3.255	+1.614	<.001	.002	3	3
LUNG_NSCLC_LUSC	CLEC18A →	+0.446	+1.903	.007	<.001	3	3
LUNG_NSCLC_LUSC	GYG1 →	+1.230	+1.876	.003	<.001	3	3
SOFT_TISSUE	EMD →	+0.651	+1.244	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREBL2 by Positive regulation of response to type II interferon activity — KIDNEY

Explore this box plot interactively →