Negative regulation of response to type II interferon

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to type II interferon pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, AIF1, and EVL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to type II interferon activity versus WAS in GBM (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.580	+0.102	<.001	<.001	3	8
GBM	AIF1 →	+0.559	+0.078	<.001	<.001	3	8
UCEC	EVL →	+0.547	+0.089	.001	.009	3	8
GBM	GPSM3 →	+0.490	+0.099	<.001	<.001	3	8
BRCA	LCP2 →	+0.447	+0.053	<.001	<.001	3	8
GBM	MYO1G →	+0.675	+0.092	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060331 vs WAS — GBM

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