Negative regulation of response to type II interferon

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, SCUBE2, and BRWD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to type II interferon activity versus BCL2A1 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCL2A1 →	+1.619	+0.768	<.001	<.001	3	6
BRCA	SCUBE2 →	-1.273	-0.409	.008	.005	3	4
BRCA	BRWD1 →	-0.519	-0.799	.001	<.001	3	4
BRCA	STX11 →	+0.449	+0.543	.002	.002	3	4
BRCA	CLEC4E →	+0.927	+0.595	.001	.003	3	4
LSCC	FPR2 →	+0.905	+0.761	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060331 vs BCL2A1 — BRCA

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