Negative regulation of response to type II interferon

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to type II interferon pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDX4, MLST8, and HCAR2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDX4 grouped by Negative regulation of response to type II interferon-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CDX4 →	+0.128	+0.322	.004	.007	3	2
OESOPHAGUS	MLST8 →	+0.120	+0.384	.003	.004	3	2
BREAST	HCAR2 →	+0.132	+0.314	.007	.008	3	2
OVARY	RHEBL1 →	-0.170	-0.233	.009	.004	2	2
OESOPHAGUS	FZD10 →	+0.449	+0.322	.006	.007	3	1
OESOPHAGUS	ATP5F1A →	+0.374	+0.384	.002	.004	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDX4 by Negative regulation of response to type II interferon activity — OESOPHAGUS

Explore this box plot interactively →