Negative regulation of response to type II interferon

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, RB1, and CACFD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to type II interferon activity versus ARHGDIB in BLOOD_Leukemia (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARHGDIB →	-1.369	-0.685	.002	.004	3	2
BLOOD_Leukemia	RB1 →	-0.739	-0.824	.003	<.001	3	2
BLOOD_Leukemia	CACFD1 →	-1.135	-0.971	.008	<.001	3	2
BLOOD_Leukemia	CRELD1 →	+1.001	+1.112	.002	<.001	3	2
PANCREAS	ZNF597 →	+0.939	+0.146	.001	.008	3	2
PANCREAS	INSIG1 →	-1.608	-0.158	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060331 vs ARHGDIB — BLOOD_Leukemia

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