Primitive erythrocyte differentiation

pathway activity — cross-omics
GO:0060319Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Primitive erythrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX29, PES1, and EBNA1BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVSNX29 →-0.382-0.082<.001<.00136
HNSCPES1 →+0.248+0.067<.001<.00135
OVEBNA1BP2 →+0.383+0.094<.001.00135
OVINPP4A →-0.217-0.081.005.00435
BRCAHLA-DPB1 →-0.456-0.045<.001.00535
CCRCCGYS1 →+0.382+0.042<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration