Cardiac epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Cardiac epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXD4, OR7E2P, and ZNF423, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac epithelial to mesenchymal transition activity versus MXD4 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MXD4 →	+0.508	+0.472	<.001	.001	3	5
CCRCC	OR7E2P →	+0.554	+0.540	.005	.008	2	6
HNSC	ZNF423 →	+0.490	+0.315	<.001	.001	2	5
HNSC	VSTM4 →	+0.627	+0.334	<.001	.003	3	4
HNSC	JAM3 →	+0.633	+0.344	<.001	.002	3	4
BRCA	IGFBP4 →	+0.838	+0.699	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060317 vs MXD4 — BRCA

Explore this scatter interactively →