Cardiac epithelial to mesenchymal transition

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac epithelial to mesenchymal transition pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Cardiac epithelial to mesenchymal transition pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and THYM, show the opposite pattern, with higher activity associated with better survival.

KIRP, THCA, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.558	0.773	<.001	134	view →
THCA	OS	Quartile	II,III,IV	0.681	1.000	.001	48	view →
MESO	OS	Tertile	All	0.264	0.523	.004	45	view →
ACC	OS	Tertile	II,III,IV	0.733	0.912	.007	24	view →
UVM	DFS	Quartile	All	0.394	0.927	.003	23	view →
COAD	DFS	Median	IV	0.325	0.609	.007	13	view →
OV	OS	Tertile	All	0.763	0.893	.003	12	view →
UCS	DFS	Median	II,III,IV	0.613	0.300	.010	12	view →
READ	OS	Tertile	III,IV	0.521	0.896	.024	12	view →
LUSC	DFS	Median	II,III,IV	0.606	0.841	.016	9	view →
SCLC	OS	Median	IV	0.201	0.772	.024	9	view →
BLCA	DFS	Tertile	IV	0.098	0.347	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0060317–KIRP (OS)

Open the KIRP breakdown →