Cardiac epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Cardiac epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL4, ATP5MC3, and TGFBR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac epithelial to mesenchymal transition activity versus MRPL4 in SOFT_TISSUE (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRPL4 →	-0.830	-0.132	<.001	.003	3	7
BONE	ATP5MC3 →	-1.125	-0.159	<.001	.001	3	7
BONE	TGFBR1 →	+1.663	+0.146	.003	.002	3	6
BONE	SLC25A19 →	-1.003	-0.124	<.001	<.001	3	6
BONE	PDCD2L →	-1.199	-0.142	<.001	.001	3	6
BONE	SLC31A2 →	+1.033	+0.119	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060317 vs MRPL4 — SOFT_TISSUE

Explore this scatter interactively →