Cardiac epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Cardiac epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYB, PDCD4, and TMEM141, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac epithelial to mesenchymal transition activity versus MYB in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYB →	+1.540	+0.995	<.001	<.001	3	5
BLOOD_Lymphoma	PDCD4 →	+1.821	+1.721	<.001	<.001	3	5
BREAST	TMEM141 →	+0.811	+0.849	.001	.005	3	5
LUNG_NSCLC_LUAD	CNTNAP3 →	-1.558	-0.621	.001	.001	3	4
LUNG_NSCLC_LUAD	EPCAM →	+2.881	+0.531	.002	.002	3	4
BLOOD_Lymphoma	ITGAV →	-1.831	-1.186	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060317 vs MYB — BREAST

Explore this scatter interactively →