Regulation of ventricular cardiac muscle cell membrane repolarization

pathway activity — cross-omics
GO:0060307Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL2, MCM5, and MCM6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ventricular cardiac muscle cell membrane repolarization activity versus DPYSL2 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECDPYSL2 →+0.416+0.059.001<.00139
LSCCMCM5 →-0.616-0.053<.001<.00139
LSCCMCM6 →-0.628-0.051<.001<.00139
LSCCMCM7 →-0.617-0.051<.001<.00139
LSCCXPO5 →-0.639-0.050<.001<.00139
UCECPRKG1 →+0.593+0.052<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060307 vs DPYSL2 — UCEC

Per-sample scatter of Regulation of ventricular cardiac muscle cell membrane repolarization activity vs DPYSL2 in UCEC.

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Exploration