Regulation of membrane repolarization

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP12, RRP1, and SYNPO2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization activity versus RRP12 in BRCA (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRP12 →	-0.306	-0.035	<.001	<.001	3	8
BRCA	RRP1 →	-0.481	-0.040	<.001	<.001	3	8
UCEC	SYNPO2 →	+0.906	+0.057	<.001	<.001	3	8
BRCA	SYNPO2_S363 →	+1.597	+0.043	<.001	.001	3	8
UCEC	TPM2 →	+1.213	+0.060	<.001	<.001	3	8
BRCA	CEBPZ →	-0.354	-0.039	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060306 vs RRP12 — BRCA

Explore this scatter interactively →