Regulation of membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN1C1, SNX27, and NAT8L, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization activity versus MAN1C1 in CNS (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAN1C1 →	-0.869	-0.059	.004	.006	3	11
BLOOD_Leukemia	SNX27 →	-0.803	-0.115	<.001	<.001	3	11
PANCREAS	NAT8L →	-1.432	-0.125	.001	.006	3	11
UPPER_AERODIGESTIVE_TRACT	CDC40 →	-0.610	-0.105	<.001	<.001	3	11
SKIN	RRAGD →	-2.301	-0.123	<.001	<.001	3	11
LIVER	PHIP →	-0.791	-0.199	.005	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060306 vs MAN1C1 — CNS

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