Regulation of cilium beat frequency involved in ciliary motility

Across TCGA patient cohorts, RNA activity of the Regulation of cilium beat frequency involved in ciliary motility pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB3P7, LINC01783, and CCDC113, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium beat frequency involved in ciliary motility activity versus HMGB3P7 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGB3P7 →	+0.482	+0.419	.008	.003	2	4
LUAD	LINC01783 →	+0.388	+0.314	<.001	<.001	3	3
LSCC	CCDC113 →	+0.464	+0.230	.004	.003	3	3
LSCC	GASK1A →	+0.462	+0.207	<.001	.009	3	3
LSCC	SMIM10 →	+0.435	+0.255	.007	.002	3	3
OV	AEBP2 →	-0.517	-0.595	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060296 vs HMGB3P7 — BRCA

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