Regulation of cilium beat frequency involved in ciliary motility

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cilium beat frequency involved in ciliary motility pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Regulation of cilium beat frequency involved in ciliary motility pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and UCEC, show the opposite pattern, with higher activity associated with better survival.

ACC, HNSC, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.793	0.446	<.001	116	view →
HNSC	DFS	Quartile	III,IV	0.255	0.482	.001	59	view →
UCEC	DFS	Quartile	All	0.965	0.860	.001	54	view →
KIRC	DFS	Tertile	All	0.726	0.583	.002	41	view →
SKCM	OS	Quartile	III,IV	0.873	0.564	<.001	37	view →
LGG	OS	Median	All	0.867	0.750	<.001	35	view →
KICH	OS	Median	All	1.000	0.708	.008	35	view →
THCA	OS	Quartile	II,III,IV	0.324	1.000	.010	34	view →
READ	OS	Tertile	All	0.736	1.000	<.001	31	view →
SCLC	DFS	Median	All	0.372	0.590	.008	22	view →
LAML	DFS	Quartile	All	0.810	0.511	.001	20	view →
DLBC	OS	Tertile	IV	0.342	0.930	.045	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0060296–ACC (OS)

Open the ACC breakdown →