Regulation of cilium beat frequency involved in ciliary motility

Across TCGA cell cohorts, RNA activity of the Regulation of cilium beat frequency involved in ciliary motility pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGR2, SEC61B, and ZCCHC17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGR2 grouped by Regulation of cilium beat frequency involved in ciliary motility-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PTGR2 →	-1.752	-1.530	.002	.001	3	4
PANCREAS	SEC61B →	+0.861	+1.219	<.001	<.001	3	4
PANCREAS	ZCCHC17 →	+0.861	+1.219	<.001	<.001	3	4
OVARY	ZNF229 →	+1.484	+0.741	<.001	.003	3	4
LUNG_NSCLC_LUSC	ELOA →	+0.491	+1.147	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLIRP →	-1.353	-1.156	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGR2 by Regulation of cilium beat frequency involved in ciliary motility activity — UPPER_AERODIGESTIVE_TRACT

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