Long-term synaptic depression

Across TCGA cell cohorts, RNA activity of the Long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCHSD1, SLC41A2, and TSEN34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCHSD1 grouped by Long-term synaptic depression-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FCHSD1 →	+2.462	+1.341	<.001	<.001	3	4
KIDNEY	SLC41A2 →	-1.405	-1.273	<.001	.003	3	4
BLOOD_Lymphoma	TSEN34 →	-1.314	-2.105	.002	<.001	3	4
STOMACH	ARHGAP26 →	+1.593	+1.413	.007	.005	3	4
STOMACH	VASN →	-3.093	-1.606	<.001	.003	3	4
OVARY	LAYN →	-2.344	-1.064	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCHSD1 by Long-term synaptic depression activity — LUNG_SCLC

Explore this box plot interactively →