Long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Long-term synaptic potentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD7, RSL1D1, and CAPN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term synaptic potentiation activity versus SETD7 in LSCC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SETD7 →	+0.200	+0.021	.006	.006	3	6
BRCA	RSL1D1 →	-0.433	-0.022	<.001	<.001	3	5
BRCA	CAPN2 →	+0.405	+0.023	<.001	<.001	3	5
UCEC	CHTF18_S871 →	-0.643	-0.034	.002	<.001	3	5
UCEC	AHCTF1_S1142 →	-0.404	-0.029	.003	<.001	3	5
LUAD	ARHGEF17_S527 →	+0.457	+0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060291 vs SETD7 — LSCC

Explore this scatter interactively →