Long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF415, PRR16, and TCN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term synaptic potentiation activity versus ZNF415 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF415 →	+0.855	+0.305	<.001	.001	3	3
LSCC	PRR16 →	+0.476	+0.346	.006	.003	3	3
LSCC	TCN2 →	+0.475	+0.173	.003	.005	3	3
LUAD	SHC2 →	+0.563	+0.188	.003	.004	3	3
LUAD	EDNRA →	+0.377	+0.197	.007	.002	3	3
LUAD	TYSND1 →	-0.318	-0.344	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060291 vs ZNF415 — LSCC

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