Long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3A3, KCNN1, and PHF14, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term synaptic potentiation activity versus SF3A3 in PANCREAS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SF3A3 →	-0.744	-0.101	.003	.001	3	9
BONE	KCNN1 →	-2.681	-0.137	<.001	<.001	3	8
BONE	PHF14 →	-1.031	-0.158	.002	<.001	2	9
OVARY	HIP1 →	-1.381	-0.107	<.001	.001	3	8
PANCREAS	LTV1 →	-0.816	-0.122	.004	.001	3	8
BONE	GAREM2 →	-1.099	-0.129	.003	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060291 vs SF3A3 — PANCREAS

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