Transdifferentiation

Across TCGA patient cohorts, RNA activity of the Transdifferentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA7, CD34, and DPT, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transdifferentiation activity versus ITGA7 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA7 →	+0.558	+0.059	<.001	.009	3	9
GBM	CD34 →	+0.846	+0.134	<.001	<.001	3	8
OV	DPT →	+0.618	+0.095	<.001	<.001	3	8
OV	MYO1C →	+0.458	+0.077	.001	.002	3	8
CCRCC	TNS2_S941 →	+0.373	+0.117	<.001	<.001	3	7
BRCA	TOP2A →	-0.820	-0.139	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060290 vs ITGA7 — BRCA

Explore this scatter interactively →