Embryonic skeletal joint morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic skeletal joint morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24B-AS1, MMP12, and ABHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal joint morphogenesis activity versus SEC24B-AS1 in PDAC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEC24B-AS1 →	+0.321	+0.268	<.001	<.001	3	4
PDAC	MMP12 →	-0.829	-0.151	.001	.008	3	4
BRCA	ABHD1 →	+0.400	+0.140	.002	.001	3	4
BRCA	ZNF862 →	+0.628	+0.159	<.001	<.001	3	4
BRCA	PRKAG2-AS1 →	+0.519	+0.120	.002	.001	3	4
BRCA	KLRA1P →	+0.508	+0.128	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060272 vs SEC24B-AS1 — PDAC

Explore this scatter interactively →