Negative regulation of respiratory burst

Across TCGA patient cohorts, RNA activity of the Negative regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSCB, NPIPP1, and GGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of respiratory burst activity versus HSCB in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSCB →	+0.417	+0.660	.001	.002	3	4
GBM	NPIPP1 →	+0.550	+0.313	<.001	.006	3	4
OV	GGA1 →	+0.558	+0.191	.001	.003	3	4
UCEC	SGPP2 →	+0.471	+0.662	.004	.002	3	3
UCEC	RN7SL718P →	+0.291	+0.640	.003	.003	3	3
GBM	IFT27 →	+0.266	+0.273	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060268 vs HSCB — UCEC

Explore this scatter interactively →