Positive regulation of respiratory burst

Across TCGA cell cohorts, RNA activity of the Positive regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF135, DLG5, and IARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF135 grouped by Positive regulation of respiratory burst-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF135 →	+1.447	+0.255	.006	.004	3	4
LUNG_SCLC	DLG5 →	+1.032	+0.255	.003	.002	2	4
LUNG_SCLC	IARS2 →	-0.773	-0.289	.001	.003	3	3
OESOPHAGUS	B3GAT2 →	-0.205	-0.172	.003	.005	3	3
STOMACH	PDZK1IP1 →	-3.337	-0.229	<.001	<.001	3	3
BONE	CMTR1 →	+0.705	+0.363	.005	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF135 by Positive regulation of respiratory burst activity — OVARY

Explore this box plot interactively →