Regulation of respiratory burst

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGPAT2, NDST1, and NCL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGPAT2 grouped by Regulation of respiratory burst-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGPAT2 →	+1.054	+0.308	.005	<.001	3	4
LUNG_NSCLC_LUSC	NDST1 →	+1.250	+0.325	.001	.007	3	4
SKIN	NCL →	-0.421	-0.340	.001	.002	3	3
SKIN	MED14 →	+0.533	+0.283	.005	.004	3	3
BLOOD_Leukemia	TMEM104 →	+0.715	+0.225	.001	.001	3	3
BLOOD_Leukemia	SLC38A10 →	+0.487	+0.239	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGPAT2 by Regulation of respiratory burst activity — BLOOD_Leukemia

Explore this box plot interactively →