Positive regulation of glial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glial cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A13, PSME3, and ANKRD20A5P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC39A13 grouped by Positive regulation of glial cell proliferation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC39A13 →	-0.247	-1.048	.005	.006	3	6
CNS	PSME3 →	-0.182	-1.340	<.001	<.001	3	6
SOFT_TISSUE	ANKRD20A5P →	-0.204	-1.285	.005	.004	3	5
STOMACH	MECP2 →	-0.513	-1.116	.001	.003	2	6
LIVER	MBOAT1 →	-0.258	-1.409	.003	.004	3	5
STOMACH	AR →	-0.123	-1.118	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC39A13 by Positive regulation of glial cell proliferation activity — OESOPHAGUS

Explore this box plot interactively →