Delamination

Across TCGA patient cohorts, RNA activity of the Delamination pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAJ26, C15orf61, and GATA2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Delamination activity versus TRAJ26 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TRAJ26 →	+1.038	+0.659	.002	.003	3	4
LUAD	C15orf61 →	-0.226	-0.668	.002	<.001	3	4
COAD	GATA2-AS1 →	-1.099	-0.624	<.001	<.001	3	3
COAD	LINC02021 →	-0.232	-0.402	<.001	<.001	3	3
LSCC	TRBJ2-4 →	+0.669	+0.495	.005	.004	3	3
LSCC	TRAV24 →	+0.295	+0.440	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060232 vs TRAJ26 — CCRCC

Explore this scatter interactively →