Delamination

Across TCGA cell cohorts, RNA activity of the Delamination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEL1L3, NME4, and KATNB1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Delamination activity versus SEL1L3 in BLOOD_Leukemia (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SEL1L3 →	+3.607	+1.386	<.001	<.001	3	1
BLOOD_Lymphoma	NME4 →	+2.835	+0.844	.004	.009	3	1
BLOOD_Lymphoma	KATNB1 →	+1.183	+1.208	<.001	.004	3	1
BLOOD_Lymphoma	PSCA →	+0.252	+1.109	.009	.007	3	1
BLOOD_Lymphoma	TARS3 →	+1.207	+0.632	.006	.006	3	1
BLOOD_Lymphoma	TMEM17 →	+0.368	+0.985	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060232 vs SEL1L3 — BLOOD_Leukemia

Explore this scatter interactively →