Mesenchymal to epithelial transition

Across TCGA patient cohorts, RNA activity of the Mesenchymal to epithelial transition pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, BMP1, and CALU, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal to epithelial transition activity versus CRTAP in PDAC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CRTAP →	+0.398	+0.048	<.001	<.001	3	7
LUAD	BMP1 →	+0.609	+0.093	<.001	<.001	3	6
BRCA	CALU →	+0.433	+0.053	.003	.008	3	6
LSCC	CCN1 →	+0.836	+0.085	<.001	<.001	3	6
GBM	FNDC3B →	+0.401	+0.090	<.001	.001	3	6
LSCC	PLOD1 →	+0.389	+0.058	.004	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060231 vs CRTAP — PDAC

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