Mesenchymal to epithelial transition

Across TCGA pan-cancer cohorts, RNA activity of the Mesenchymal to epithelial transition pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Mesenchymal to epithelial transition pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, UVM, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.424	0.785	<.001	82	view →
UVM	DFS	Median	III,IV	0.780	0.333	<.001	56	view →
SKCM	OS	Tertile	III,IV	0.643	0.282	<.001	44	view →
KIRC	DFS	Tertile	All	0.554	0.712	.010	38	view →
THCA	OS	Tertile	II,III,IV	1.000	0.674	.012	30	view →
LGG	DFS	Quartile	All	0.719	0.839	.007	19	view →
BLCA	OS	Tertile	IV	0.685	0.431	.004	18	view →
COAD	DFS	Quartile	II,III,IV	0.383	0.660	.003	16	view →
ESCA	DFS	Median	III,IV	0.622	0.314	.001	12	view →
CESC	OS	Quartile	III,IV	0.882	0.509	.014	12	view →
PCPG	OS	Quartile	All	0.783	1.000	.028	9	view →
LUSC	OS	Median	IV	0.255	0.851	.021	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0060231–ACC (OS)

Open the ACC breakdown →